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About Us

Located in the Department of Molecular and Cellular Biology at the University of Adelaide, Australia, our research focuses on the host response, basic molecular virology and pathogenic mechanisms of disease for viruses belonging to the flaviviridae family, including Hepatitis C Virus (HCV), Dengue Virus (DENV) and Zika Virus (ZIKV).

Learn more about our research and areas of study below

Recent News

Michael travelled to Umea, Sweden to be on the PhD defence committee  for Arun Upadhyay. Congratulations Arun!

Upcoming ACH2 2017 meeting at the Barossa Valley. June 7-9 

Michael and Colt attended the  Lorne Infection and Immunity  meeting.  February 2017 

Michael will be attending the Gordon Research Conference - Viruses and Cells in Tuscany, Italy

RESEARCH FOCUS

Innate Immune Response to Viral Infection

Infection of the cell results in activation of an  innate immune response and expression of antiviral interferon stimulated genes (ISGs). We are interesed in which ISGs control viral infecion and their machansim of action.

HCV

170 million: that’s how many people around the world are infected with HCV. For many of those people, this infection will result in significant liver disease and cancer. HCV infection is now the leading indication for liver transplantation in many countries including Australia



ZIKV

Currently an epidemic in the Americas,  ZIKV can cause microcephaly in newborns. We are investigating the response of the placenta and the neonatal brain to ZIKV infection in the hope of understanding ZIKV pathogenesis. 


DENV

Responsible for many deaths worldwide in developing countries, capable of causing dengue haemorhagic fever and shock syndrome

Recent Publications

Viperin is antiviral against ZIKV

Sensitive luminescent reporter viruses reveal appreciable release of HCV NS5A protein into the extracellular environment

HCV RNA traffic and association of NS5A in living cells

Phosphorylation of NS5A serine-235 is essential for HCV RNA replication and normal replication compartment formation

The interferon-induced transmembrane proteins, IFITM1, IFITM2, and IFITM3 inhibit hepatitis C virus entry

Generation of a chimeric hepatitis C replicon encoding a genotype-6a NS3 protease and assessment of boceprevir (SCH503034) sensitivity and drug-associated mutations

Dynamic imaging of the hepatitis C virus NS5A protein during a productive infection

Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin

 Signal transducer and activator of transcription 3 is a proviral host factor for hepatitis C virus

Calsyntenin-1 mediates hepatitis C virus replication

Personnel

Michael Beard

Lab Head

Nick Eyre

Post-Doc

Kylie Van der Hoek

Post-Doc

Catherine Scougall

Lab Technician

Yulee Khanti

PhD Candiate

Colt Nash

PhD Candidate

Byron Shue

PhD Candidate

Chuan Lim

PhD Candidate

Rosa Coldbeck-Shackley

Masters Candidate

Daniel Anfiteatro

Honours Candidate

Funding

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